Research teams and research areas

The Institut de la Vision brings together nearly 300 researchers in 18 research units specialized in ophthalmological pathologies. At the forefront of scientific innovation, these units conduct translational research aimed at developing cutting-edge technological solutions and therapeutic innovations for the prevention, diagnosis and treatment of these pathologies. Organized around five strategic research axes, the teams of the Institut de la Vision cover a wide range of topics, from the molecular physiology of vision to innovative therapeutic approaches.

Retinal development and repair

We are working on cell therapy using the implantation of stem cell-derived retinal cells. This constitutes a therapeutic option for the treatment of retinal degenerative diseases, affecting photoreceptors and retinal pigment epithelial cells.

Olivier Goureau Research director
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Our team is at the forefront of the development of cell-based therapies to tackle degenerative diseases of the retina, such as hereditary retinal dystrophies and age-related macular degeneration (AMD). We focus on basic and translational research using human induced pluripotent stem (iPS) cells to create 3D retinal avatars, called retinal organoids, by recapitulating human retinogenesis.

The aims of our laboratory are to use these organoid models to gain a better understanding of the cellular and molecular events that occur during human retinal development, and to generate retinal cells and tissues that can be used for modelling retinal diseases and developing different types of cell therapy.

Research areas

  • Pluripotent stem cells
  • Organoids
  • Cell therapy
  • Disease Modeling

Team members

Olivier Goureau Research director
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Gaël Orieux
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Sacha Reichman Group Leader, Research associate
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Amélie Slembrouck
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Céline Nanteau
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Jeremy Brogard
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Clarisse Andres
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Gaëlle Girard
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Manon Lancien
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Elise Leger
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Lisa Thonon
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Sophie Tran
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Marilou Clémencon
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Scientific publications

Below you will find the latest scientific publications in this field: Retinal development and repair.

From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium

Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot E, Sahel J-A, Monville C and Goureau O.
Proc. Natl. Acad. Sci. USA 2014, 111, 8518-8523

Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions

Reichman S, Slembrouck A, Gagliardi G, Chaffiol A, Terray A, Nanteau C, Potey A, Belle M, Rabesandratana O, Duebel J, Orieux G, Nandrot EF, Sahel JA and Goureau O.
Stem Cells 2017 35(5):1176-1188

Clinically compatible human ESC-derived RPE cells grafted as an epithelium potentiates vision rescue in dystrophic rodent

Ben M'Barek K, Habeler W, Plancheron A, Jarraya M, Regent F, Terray A, Yang Y, Chatrousse L, Masson Y, Sahel JA, Peschanski M, Goureau O. and Monville C.
Sci. Transl. Med. 2017, Dec 20;9(421)

Characterization and transplantation of CD73-positive photoreceptors isolated from human iPSC-derived retinal organoids

Gagliardi G, Ben M'Barek K, Chaffiol A, Slembrouck-Brec A, Conart JB, Nanteau C, Rabesandratana O, Sahel J-A, Duebel J, Orieux G, Reichman S, and Goureau O.
Stem Cell Rep. 2018, 11(3):665-680

Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined. Human brain organoids assemble functionally integrated bilateral optic vesicles

Rodrigues A, Slembrouck-Brec A, Nanteau C, Terray A, Tymoshenko Y, Zagar Y, Reichman S, Xi Z, Sahel J-A, Fouquet S, Orieux G, Nandort EF, Byrne LC, Audo I, Roger JE and Goureau O.
npj Regen. Med. 2022, Aug 16;7(1):39

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