OptiCELL
Bioengineered stem cell-derived retinal cells and tissue for cell therapy
OptiCELL aims to develop a new generation of bioengineered retinal tissues derived from stem cells, combining optogenetics and tissue engineering for innovative applications in retinal cell therapy.
Features
Project duration
48 months
Start :
End :
Project scale
National project
Allocated budget
2 300 000 €
Description
The OptiCELL project develops a regenerative medicine approach based on stem cell-derived cell therapy. Its objective is to design alternative outer retinal cell therapy products derived from human pluripotent stem cells that integrate optogenetics and/or tissue engineering, enabling the transplantation of functional cells. The project therefore aims to:
- deploy larger-scale, automated production processes compliant with Good Manufacturing Practices (GMP);
- optimize final cell therapy products intended to replace photoreceptors and/or the retinal pigment epithelium (RPE);
- develop non-destructive, low-cost quality controls based on artificial intelligence.
OptiCELL is an awarded project among the first to be funded under the Priority Research Programme and Equipment (PEPR) “Biotherapies and Bioproduction of Innovative Therapies”, part of the national acceleration strategy aimed at positioning France at the forefront of biotherapies and the bioproduction of innovative therapeutic solutions.
Programme
PEPR Biothérapies et Bioproduction de Thérapies Innovantes (France 2030)
The Biotherapies and Bioproduction of Innovative Therapies (BBTI) Research Program (PEPR), launched by the French government in 2021, is one of the major initiatives in the Biotherapies and Bioproduction of Innovative Therapies acceleration strategy of the France 2030 plan.
This research program, whose scientific management has been entrusted to Inserm and CEA, aims to contribute to the development of tomorrow’s biotherapies and associated key technologies.
It also aims to federate the national academic research ecosystem and promotes close links with industry and hospitals.
The PEPR is part of a wider drive to consolidate France’s leadership and competitiveness in this sector research and manufacturing processes.
Project team
Partners
