Postdoctoral position available in Immune responses and Ocular diseases
Context
A two-year (one-year renewable fixed-term contract) postdoc position funded by ANR is available at the Institut de la Vision (IDV) for a highly motivated postdoctoral researcher to understand the molecular and cellular mechanisms underlying immune dysfunctions in several eye diseases.
The eye is an immune-privileged site, with mechanisms to suppress inflammation for maintaining visual function. However, this privilege can be disrupted in autoimmune uveitis when immune cells infiltrate the eye, leading to potential vision loss. Conversely, in uveal melanoma, tumor cells exploit the eye's immune privilege to evade detection, making treatment challenging. Understanding these mechanisms is crucial for developing therapies that restore immune balance in uveitis and overcome immune evasion in uveal melanoma.
The IDV is one of the leading European research centers focused on ocular diseases. It unites researchers, clinicians, and industry partners under one roof to advance the discovery, testing, and development of treatments and technological innovations that benefit visually impaired patients. Postdocs also benefit from professional development opportunities at both the IDV and Sorbonne University.
The research team
The successful candidate will join the "Inflammation and Immunology in Retinal Diseases" team, a dynamic, diverse, and multidisciplinary research team with expertise ranging from molecular to cellular mechanisms.
Inflammation and Immunology in Retinal Diseases | Institut de la vision
Missions
The post-doc's work will involve carrying out spatial proteomics experiments to understand the molecular and cellular mechanisms underlying immune dysfunction in an intraocular tumour, uveal melanoma.
Main activities:
- Carrying out space proteomics experiments - MACSima technology,
- Image processing and analysis,
- Bioinformatics and statistical analysis of data,
- Presentation and publication of scientific results,
- Scientific and technological watch,
- Supervision of students.
Skills required
Cross-disciplinary knowledge required :
- Scientific knowledge of immunology
- Good command of scientific English (written and spoken)
Skills :
- Ability to work independently and manage a research project
- Design and carry out experiments
- Present results at meetings and conferences
- Write a project, a report and a scientific article
People skills :
- Good interpersonal skills and ability to work as part of a team
- Organisation and rigour
- Ability to summarise
Candidates whose profiles partly overlaps the requirements but who have a strong interest in acquiring the other expertise are also encouraged to apply.
Education and experience
- PhD in biology (Immunology / Oncology / Neuroscience)
- Experience in image analysis
- Experience in bioinformatics analysis
Specific working conditions
Please apply by email only to Ms Cécile DELARASSE (cecile.delarasse@inserm.fr) and send her the following documents in PDF format:
- a detailed curriculum vitae (CV),
- a covering letter with a declaration of interest in research and a summary of previous research activities,
- at least two letters of reference
How to apply
To apply for this vacancy, please complete this form and attach your cover letter and curriculum vitae in .pdf format. We will get back to you as soon as possible.