Leber’s congenital amaurosis

Leber's congenital amaurosis (LCA) is a rare retinal dystrophy that severely affects vision in early life. LCA is most often inherited in an autosomal recessive manner and is genetically heterogeneous. The disease was first described in 1869 by the German ophthalmologist Theodor Karl Gustav Leber. LCA should not be confused with Leber's hereditary optic neuropathy (LHON), which is a distinct eye disease leading to visual impairment.