Most cases of retinoschisis are innocuous and do not affect central vision. Treatment (laser surgery, incisional surgery) should be considered only in symptomatic cases that threaten the macula and in cases with progressive retinal detachment.

Observation for asymptomatic cases is indicated. The frequency of the routine review depends upon the lesion size, the proximity to the macula and the presence or absence of symptoms (6-24 month intervals). Patients should be advised to return urgently if they experience retinal detachment symptoms, such as increased floaters or flashing lights or the presence of a curtain or shadow in their field of vision.