Nicol, Ros et al. have developed SponGee, a genetically encoded cGMP chelator that allows the manipulation of this second messenger in individual cells with subcellular specificity. SponGee modifies the migration of cortical neurons in development in vivo. The targeting of SponGee's lipid raft prevents axonal repulsion, unlike the exclusion of this subcellular compartment.

SponGee enables the investigation of local cGMP signals in vivo and paves the way for therapeutic strategies that prevent downstream signaling activation

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