18th March 2020, 14h00 - 15h00
(Conference room 13 rue Moreau)

Alberto Bacci (Brain & Spine Institute (ICM, Hôpital Pitié Salpêtrière, Paris France)

Invited by: Angelo Arleo

In the neocortex, perisomatic inhibition onto principal pyramidal neurons (PNs) determines the dynamic range of pyramidal neuron responses during sensory processing and drive several forms of network oscillations, believed to be the network correlate of several cognitive functions. The inhibitory control of the perisomatic region of PNs originates mainly from a GABAergic interneuron subtype the: parvalbumin (PV)-expressing basket cell. I will describe a PV cell-specific microcircuit: autaptic self-inhibition, which represents an exceptionally large and fast disinhibitory mechanism, favoring synchronization of PV-cell firing during cognitive-relevant cortical network activity. I will also discuss how activity-dependent plasticity of perisomatic inhibition effectively influences the participation of single PNs to γ-oscillations. This work highlights specific strategies operated by PV cells in controlling the output spikes of PNs during cortical activity.

Alberto Bacci joined the ICM in 2011, with his team “Cellular physiology of cortical microcircuits”. He received a MSc in 1994 and a PhD in experimental pharmacology and therapeuthics from University of Milano in 2000, and did postdoctoral work at the Department of Neurology of Stanford University. He is recipient of several awards and his research has been and is currently supported by the ERC, Giovanni Armenise-Harvard Foundation, NARSAD. Alberto Bacci’s team aims at gaining more detailed information on the properties of neocortical interneurons, using a combination of electrophysiological, cellular, biochemical and morphological techniques. The ultimate goal of his research is to understand the functional relevance of these different neuron subtypes within cortical circuits.