12th February 2019, 13h00 -14h00
(Passage d’innovation - 74, rue du Faubourg Saint Antoine)

Complete title:
An unconventional myocardin-related transcriptional factor (MRTF)-directed signaling axis in cell migration and angiogenesis – basic science and translational opportunities

Partha Roy (Associated Professor, Bioengineering and Pathology, University of Pittsburgh;

Invited by Florian Sennlaub and Xavier Guillonneau

Directed cell migration plays an important role in embryonic development, wound healing, angiogenesis, immune response, cancer invasion and metastasis. Dynamic reorganization of actin cytoskeleton, a key aspect of cell migration, is regulated by the concerted actions of various classes of actin-binding proteins (ABPs), and some of these ABPs are fundamental drivers of actin-based cell motility. Altered expressions and activities of fundamental drivers of cell migration lead to aberrant cell motility in pathologic scenarios. Our main research interests are to: a) gain novel insights on how dysregulation of fundamental drivers of cell migration contributes to metastatic progression of solid cancers and pathological angiogenesis; and b) develop translational strategies exploiting the pathways of dysregulation as a means to suppress metastatic phenotype of cancer cells and angiogenesis-dependent pathology. This talk will focus on an unconventional function of Myocardin-related transcriptional coactivator MRTF (links actin dynamics to transcriptional regulation of many cytoskeletal and adhesion-related genes) in the context of cell migration and angiogenesis, and further assessment of novel small molecules targeting a specific ABP downstream of MRTF function as anti-angiogenic agents with potential use in retinal diseases.