DONATE MAINS

Main objective

Development of optoretinography on adaptive optics and/or OCT devices for the evaluation of retinal function

Description

This position joins the project funded by ERC Consolidator Grant OPTORETINA in Kate Grieve’s group aimed at developing tools for measuring retinal function to support the development and monitoring of gene therapies. In particular, the purpose is to develop optoretinography (ORG) on adaptive optics (AO) and/or optical coherence tomography (OCT) ophthalmoscopes. ORG involves functional imaging of the intrinsic signal of retinal cells. It measures, using optical methods, light-induced neural responses in the retina, and can be considered the optical analogue of electroretinography (ERG) and functional magnetic resonance imaging (fMRI). Optoretinography aims to provide a non-invasive measurement of photoreceptor function in response to a visible light stimulus via near-infrared light imaging. Based on the assumption that retinal cellular function and visual perception can be detected using this optical approach, the overall goal of this development is to ultimately enable quantitative functional assessment of cellular activity in vivo in the context of gene and cell therapies.

Missions

The objectives of the postdoctorate are, among other things, to define and conduct stimulation and imaging protocols on OA and/or OCT ophthalmoscopes, to optimize or develop ORG algorithms with the team on MATLAB and to analyze and interpret data.

This work will be carried out in interaction with researchers, doctors, engineers and technicians from the Paris Eye Imaging group. The recruitment of a postdoctoral fellow with a good background in physics in general and optics in particular, as well as a marked interest in imaging technology for ophthalmology and medecine is desirable.

Qualifications required or desired

• PhD in biomedical optics, bioengineering, physics.
• The candidate will have initial experience in optics and computer science with a taste for biomedical applications and image processing. Knowledge of biology would be appreciated.
• The management and interpretation of images generally use the MATLAB and/or Python language with which the candidate should be familiar.

Job contract and terms

temporary contract of 1 year, renewable

Job location

Vision Institute, 17 Rue Moreau, 75012 Paris

Recruitment methods

Deadline for applications: January 27, 2023
Start of contract: earliest March 1, 2023
The contact for your application (cover letter, CV) is Kate Grieve (kate.grieve@inserm.fr)

Download the offer