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Our research

Our research

Scientific research activities take up three floors in the 6,000 m2 building and group more than 200 scientists (Inserm - UPMC - CNRS) specialized in vision disorders. There are more than 15 research teams grouped in four departments.

 

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The Institut de la Vision coordinates or is involved in major projects supported by national and international agencies and foundations.


LIGHT4DEAF

This program is dedicated to the fight against Usher Syndrome and is coordinated by Professor José-Alain Sahel, Director of the Vision Institute (Inserm / UPMC / CNRS) and Professor Christine Petit, researcher at the Pasteur Institute. Usher Syndrome is the most frequent cause of inherited deaf-blindness in humans and one of the most devastating sensory impairment. With a prevalence of 1/10000, it represents 50% of all monogenic deaf-blindness cases. Patients’ and relatives’ response to Usher Syndrom diagnosis include shock, denial, confusion, devastation, and “no plans, no hope”.
The LIGHT4DEAF initiative is designed to implement a major, concerted and interdisciplinary effort between scientists, ENT specialists, ophthalmologists and vestibular, neuro-cognitive and human sciences experts in order to address unmet Usher Syndrome patients’ clinical needs.

With the support of:

Investissements davenir     logo anr


LABEX LIFESENSES

The objective of this important project is to address conditions of visual and auditory deficits rarely or entirely untreated, particularly in the context of aging. The LABEX LIFESENSES (Laboratory of Excellence) is supported by French state funds managed by the ANR within the Investissements d'Avenir programme.

With the support of:

Investissements davenir     logo anr


Institut Carnot Voir & Entendre

CARNOT 1105 Voir et Entendre

The Institut de la Vision is part of the "Voir & Entendre" Carnot Institute, which represents one of the most important international centers in neurosensory research. This institute is designed as a place of exchange, gathering on the same site patients, clinicians, researchers and industries in order to accelerate innovation in terms of health products and high technology, while bringing solutions to unmet needs of people impaired by pathologies and handicaps affecting visual and hearing systems. The Institut Carnot Voir et Entendre is supported by the ANR.

With the support of:

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Carnot International GLOBAL CARE

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The GLOBAL CARE Initiative is a consortium of 5 French research institutes joined to develop their collaborative and partnership research in human health worldwide. It puts together researchers and a wide array of technical assets and expertise for business development and research. Based in France (Paris & Lyon), the GLOBAL CARE Initiative is an efficient and high quality springboard towards International success for RTO, Pharma and Biotech. The Carnot International GLOBAL CARE is supported by the ANR.

With the support of:

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DHU Vision and Handicaps

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The Institut de la Vision is part of the «Département Hospitalo-Universitaire (DHU) Vision and Handicaps». The DHU brings together care units of the "Assistance de Paris Hôpitaux de Paris (APHP), of the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, and the Fondation Ophtalmologique Rothschild, affiliated to three major universities: the UPMC, the UVSQ, the University of Paris 7 and the University of Paris 13. In the frame of the DHU, clinical and fundamental research as well as medical education will be strongly promoted. The objectives of the DHU Vision and Handicaps include prevention, screening, and management of ocular conditions which are sources of disability and of visual impairment in patients with associated disabilities.


ERC Synergy "Helmholtz"

The European Research Council (ERC) selected in 2013 thirteen projects from nearly 450 applications for the prestigious Synergy Grant. Each project brings together two to four eminent researchers working at the crossroads of multiple disciplines. The Helmholtz project is one of the winning projects. It combines the scientific expertise of the Institut de la Vision and of the Institut Langevin to develop advanced diagnostic and to monitor non-invasive imagery methods permitting real-time investigation of the structure and function of retinal cells and vessels.

With the support of:

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ECOMODE

ECOMODE (H2020 ICT) aims at exploiting the recently matured biologically-inspired technique of event-driven compressive sensing (EDC) of audio-visual information to implement touch-less device control/interaction based on gesture and vision-assisted speech recognition. The final goal of the project is to demonstrate that the proposed technology is particularly suited to support the diverse user group of the visually impaired and the elderly, and to facilitate their interaction with modern ICT devices and hence improve their potential to better participate in a modern, interconnected society. The project consortium is composed of 7 international partners and coordinated by the Institut de la Vision (UPMC). The ECOMODE is funded by the European Commission H2020.

With the support of:
horizon 2020


ERC OPTOGENRET
"Microbial opsins for mammalian vision: Optogenetics in the retina"

One of the aims of this project is to restore vision in retinal degenerative diseases such as Retinitis pigmentosa by the insertion of microbial opsins into retinal neurons. Another aim is to investigate the structure and function of retinal interneurons, which mediate the remarkable image processing capabilities of the retina, by using optogenetics in combination with two-photon microscopy and electrophysiology. OptogenRet is supported by the European Research Council.

This ERC project has been presented in a article "A new vision for treating retinal blindness", in the Spring 2016 issue of the EU Research magazine.

With the support of:

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ERC REGENERETH
"Modeling and treating retinal degenerative diseases"

The creation of models of diseases in primates combined with novel AAVs tested in human post-mortem retinas will enable us to validate therapies aiming at vision restoration and neuroprotection in retinas with a macula and high central visual acuity, removing a major roadblock in the development of ocular therapeutics for humans. The REGENERETH is supported by the European Research Council.

With the support of:

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ERC BRAINSTRUCT
"Building up a brain: understanding how neural stem cell fate and regulation controls nervous tissue architecture"

The experiments of this project will reveal how neural stem cell output might be regulated by cell interactions and intercellular signals. This multidisciplinary project will set the basis for quantitative analysis of brain development with single-cell resolution in normal and pathological conditions. The BRAINSTRUCT is supported by the European Research Council.

With the support of:

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Human Brain Project (HBP): aCORE and CLAP

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The Institut de la Vision contributes to the main aim of the HBP to better understand the human brain. It is involved in the following sub-projects: SP4 - Mathematical and Theoretical Foundations of Brain Research and SP11 - Applications. Both sub-projects are supported by the European Union.

 


Brain Initiative
"Three dimensional holography for parallel multi-target optogenetic circuit manipulation"

Obama has announced a 100 million dollar brain mapping project

The project consortium (5 participants) proposes to: (1) characterize newly developed opsins to determine which are best suited for holographic activation techniques; (2) implement holographic light patterns in three-dimensions; and, (3) distribute and iteratively optimize the 3D holography system in collaboration with Neuroscientists studying circuits in optically and physiologically diverse neural systems. The end goal is to develop a robust system, capable of manipulating neurons in patterns that mimic naturally occurring activity. The project is funded by the NIH (National Institutes of Health) in the frame of the BI

With the support of:

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FFB Paris Center for Translational Research on Retinal Degenerations

The Paris center represents an ambitious integrated set of modules aiming at a better understanding and, above all, at developing and validating novel therapies for retinal degenerations, namely retinal dystrophies and age-related-macular degeneration (AMD). The FFB Paris Center is supported by the Foundation Fighting Blindness.

With the support of:

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FFB Translational Research Acceleration Program (TRAP)

The Institut de la Vision is developing an optogenetic gene therapy based on an adeno-associated virus to reactive cones in people with advanced retinal degeneration from conditions such as retinitis pigmentosa. Its goal is to launch a clinical trial of the emerging treatment. The FFB TRAP is supported by the Foundation Fighting Blindness.

With the support of:

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SIGHT AGAIN

SIGHT AGAIN is a collaborative research and development project, which aims at restoring vision to legally blind patients with retinitis pigmentosa at different stages. SIGHT AGAIN is coordinated by GenSight Biologics, with two  participants: Pixium Vision and the Fondation Voir & Entendre. This project is based on a unique public - private partnership, supported by Bpifrance in the frame of the Investissements d'Avenir.

With the support of:

BPI France RVB fd blanc


SILVERSIGHT Research chair "Aging in Vision and Action"

SilverSight

The research led in the frame of SILVERSIGHT aims at enhancing the fundamental understanding about specific underlying factors altering perceptive and spatial cognitive aspects of visual aging. The chair is supported by ESSILOR and the UPMC.

With the support of:

ESSI G GREYUPMC new