DONATE MAINS

Retinal development and repair: use of pluripotent stem cells

Return

Team leader: Olivier Goureau

  • Genetic Slide 1
  • Genetic Slide 2
  • Genetic Slide 3


Introduction

We are working on cell therapy using the implantation of stem cell-derived retinal cells. This constitutes a therapeutic option for the treatment of retinal degenerative diseases, affecting photoreceptors and retinal pigment epithelial cells.

Presentation

Inherited and acquired degenerative diseases of the retina are a significant cause of incurable vision loss worldwide. Rescuing the degenerated retina is a major challenge for which specific cell replacement is one of the most promising approaches. Our laboratory utilizes human induced pluripotent stem (iPS) cell technology to generate different retinal cell types for cell-based rescue or replacement strategies and for use in human retinal disease modeling. To meet these goals, we followed different objectives:

  • Generation human fluorescent reporter iPS cell lines to probe retinal differentiation process ;

  • Development of innovative and robust protocols allowing the differentiation of human iPS cells into different retinal cell types (retinal ganglion cells, photoreceptors and RPE cells) ;

  • Derivation of iPS cells from patients affected by specific inherited retinal dystrophies to understand retinal pathological mechanisms and to further develop large-scale drug screening.

Research areas

  • Pluripotent stem cells

  • Retinal development

  • Retinal degeneration

  • Cell therapy



TO DOWNLOAD THE ALUMNI PDF 

Publications

 


Support

  • ANR
    ANR
  • SANOFI
    SANOFI
  • ile de france
    ile de france
  • FAF
    FAF
  • Fondation de france
    Fondation de france
  • SATT Lutech
    SATT Lutech
  • Revive Labex
    Revive Labex
  • Retina France
    Retina France
  • Unadev
    Unadev
  • AFM
    AFM


SUPPORT  Coeur mains