DONATE MAINS

A 3-years-PhD position is available at the Institut de la Vision

Principal investigator Christina Zeitz in collaboration with Serge Picaud

Identification and characterization of genes implicated in myopia

Myopia is the most common human eye disorder characterized by sharp near vision but blurred distance vision. Epidemiological studies have shown that the prevalence of myopia has increased by up to 30% in Europe and the United States and up to 80% in some Asian countries. It is estimated that half of the world's population will be myopic by 2050. Myopia often leads to serious blinding complications such as retinal detachment and macular degeneration and represents a major risk for the development of glaucoma and cataracts. The development of myopia is controlled by environmental and genetic factors. Light is an important factor in the development and prevention of myopia. Outdoor activities have a protective effect against the development and progression of myopia. Similarly, genetic studies in patients and animal models have shown that genes important for light-induced retinal signaling play a role in the development of myopia and influence the control of circadian rhythm.

The objectives of this project are to better understand the effect of retinal information processing in the development and progression of myopia.

Candidates should hold a diploma or a master’s degree in Genetics, Neuroscience or Developmental Biology. Experience in animal experimentation would be a plus. Knowledge in retina pathophysiology and RNAseq data interpretation would be appreciated but is not required. The candidate should be highly motivated and organized, have good communication skills and a team-oriented work style. The candidate should speak and write English fluently.

Candidates should send the application (in a PDF-format) before April 3rd to Dr. Christina Zeitz (christina.zeitz@inserm.fr), including a CV and a motivation letter mentioning two references.