Pathophysiology of the anterior segment of the eye

Team leader: Annabelle Reaux-Le Goazigo

Introduction

We study the physiopathology of the anterior segment of the eye, with special interest in glaucoma, dry eye disease, and ocular pain. We also investigate the role of chemokines which could be involved in the mechanisms of these diseases and act as biomarkers and/or therapeutic targets.

Presentation

Glaucoma is the second leading cause of blindness in the world and we are analyzing the efficacy of cellular therapies on glaucoma pathology to reduce intraocular pressure and protect retinal ganglion cells from cell death. Our research also includes studies of neuroinflammatory and neurodegenerative mechanisms occurring during glaucoma pathology in the central visual areas using several biochemical approaches and the intracellular signaling pathways responsible for the anti-apoptotic and relaxant effects of new molecules and mesenchymal stem cells on trabecular cells in vitro.

In the area of ocular surface disease, we are developing a number of in vitro and in vivo models to demonstrate the core role played by epithelial cells during inflammatory processes. We have validated the conjunctival HLA-DR as a gold standard marker of inflammation whose positive correlation with clinical signs of dry eye indicates the therapeutic effects of immunomodulating strategies. Our team is reinforcing its translational research on biomarkers with new techniques and a genomic-based systematic screening approach in a variety of ocular surface diseases. In addition, we are characterizing chronic corneal trigeminal pain at the cellular, molecular, and behavioral levels with particular interest in neuroimmune interactions that occur in the cornea, trigeminal ganglion, and the brainstem. We are also analyzing the role of chemokines (proalgic) in the modulation of ocular pain processing and their possible cross talk with the opioid (analgesic) system.

Research areas

Neuroinflammation and neurodegeneration mechanisms in the pathology of glaucoma.
The role of epithelial cells during inflammatory processes in the ocular surface underlying the pathophysiology of dry eye.
The role played by chemokines in the modulation of ocular pain processing and their interaction with the opioid system.

Publications

Updated and complete list by scientist
Visiting the ORCID links you will find the updated publications list for the following scientists:
- Christophe Baudouin [>>]
- Stéphane Melik Parsadaniantz [>>]
- Annabelle Réaux - Le Goazigo [>>]
- William Rostene [>>]
2019

IgE Ratio in Tears: A Predictive Tool of Ocular Allergic Inflammation.
Neil J, Kessal K, Merabet L, Kobal A, Bouhadiba S, Poilane C, Riancho L, Bury T, Baudouin C, Brignole-Baudouin F.
Ocul Immunol Inflamm. 2019 Aug 14:1-11. doi: 10.1080/09273948.2019.1629462.
PMID:31411517

Correlation of clinical symptoms and signs with conjunctival gene expression in primary Sjögren syndrome dry eye patients.
Liang H and Kessal K, Rabut G, Daull P, Garrigue JS, Melik Parsadaniantz S, Docquier M, Baudouin C, Brignole-Baudouin F.Ocul Surf. 2019 Mar 21. pii: S1542-0124(18)30219-2. doi: 10.1016/j.jtos.2019.03.005. [Epub ahead of print]PMID:30905840

Modulation of Inflammation-Related Genes in the Cornea of a Mouse Model of Dry Eye upon Treatment with Cyclosporine Eye Drops.
Daull P, Barabino S, Feraille L, Kessal K, Docquier M, Parsadaniantz SM, Baudouin C, Garrigue JS.
Curr Eye Res. 2019 May;44(5):476-485. doi: 10.1080/02713683.2018.1563197. Epub 2019 Jan 21.
PMID:30664361
2018

Conjunctival Inflammatory Gene Expression Profiling in Dry Eye Disease: Correlations With HLA-DRA and HLA-DRB1.
Kessal K, Liang H, Rabut G, Daull P, Garrigue JS, Docquier M, Melik Parsadaniantz S, Baudouin C, Brignole-Baudouin F.
Front Immunol. 2018 Oct 15;9:2271. doi: 10.3389/fimmu.2018.02271. eCollection 2018.
PMID:30374345

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study.
Herbaut A, Liang H, Rabut G, Trinh L, Kessal K, Baudouin C, Labbé A.
Transl Vis Sci Technol. 2018 Jul 12;7(4):5. doi: 10.1167/tvst.7.4.5. eCollection 2018 Jul.
PMID:30009091

Formaldehyde Gas Exposure Increases Inflammation in an In Vitro Model of Dry Eye.
Vitoux MA, Kessal K, Baudouin C, Laprévote O, Melik Parsadaniantz S, Achard S, Brignole-Baudouin F.
Toxicol Sci. 2018 Sep 1;165(1):108-117. doi: 10.1093/toxsci/kfy125.

Controlled Adverse Environment Chambers in Dry Eye Research.
Calonge M, Labetoulle M, Messmer EM, Shah S, Akova YA, Boboridis KG, Merayo-Lloves J, Aragona P, Benítez-Del-Castillo J, Geerling G, Rolando M, Baudouin C.
Curr Eye Res. 2018 Apr;43(4):445-450.

Topical ocular 0.1% cyclosporine A cationic emulsion in dry eye disease patients with severe keratitis: experience through the French early-access program.
Pisella PJ, Labetoulle M, Doan S, Cochener-Lamard B, Amrane M, Ismail D, Creuzot-Garcher C, Baudouin C.
Clin Ophthalmol. 2018 Feb 5;12:289-299.

Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study.
Augstburger E, Zéboulon P, Keilani C, Baudouin C, Labbé A.
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):870-877.

Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III clinical studies.
Leonardi A, Messmer EM, Labetoulle M, Amrane M, Garrigue JS, Ismail D, Sainz-de-la-Maza M, Figueiredo FC, Baudouin C.
Br J Ophthalmol. 2018 Mar 15. pii: bjophthalmol-2017-311801. doi: 10.1136/bjophthalmol-2017-311801.

Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.
Nicolle P, Liang H, Reboussin E, Rabut G, Warcoin E, Brignole-Baudouin F, Melik-Parsadaniantz S, Baudouin C, Labbe A, Reaux-Le Goazigo A.
Int J Mol Sci. 2018 Apr 17;19(4). pii: E1221. doi: 10.3390/ijms19041221.

Expression of cytokines in aqueous humor from fungal keratitis patients.
Zhang Y, Liang Q, Liu Y, Pan Z, Baudouin C, Labbé A, Lu Q.
BMC Ophthalmol. 2018 Apr 19;18(1):105.

Neurotrophic keratopathy.
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Gerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C.
Prog Retin Eye Res. 2018 Apr 23. pii: S1350-9462(17)30121-0. doi: 10.1016/j.preteyeres.2018.04.003.

The Efficacy of Deep Sclerectomy on Posture-induced Intraocular Pressure Changes.
Aragno V, Labbé A, Brion F, Baudouin C, Hamard P.
J Glaucoma. 2018 May 11. doi: 10.1097/IJG.0000000000000971.
2017

Three-dimensional distribution of tyrosine hydroxylase, vasopressin and oxytocin neurones in the transparent postnatal mouse brain.
Godefroy D, Dominici C, Hardin-Pouzet H, Anouar Y, Melik-Parsadaniantz S, Rostène W, Reaux-Le Goazigo A.
J Neuroendocrinol. 2017 Dec;29(12). doi: 10.1111/jne.12551.

In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography.
Ghouali W, Tahiri Joutei Hassani R, Djerada Z, Liang H, El Sanharawi M, Labbé A, Baudouin C.
PLoS One. 2017 Nov 27;12(11):e0187864.

International publication trends in dry eye disease research: A bibliometric analysis
Boudry C, Baudouin C, Mouriaux F.
Ocul Surf. 2017 Oct 11. pii: S1542-0124(17)30129-5.

Efficacy of Two Trabecular Micro-bypass Stents During Phacoemulsification for Mild to Advanced Primary Open-angle Glaucoma Controlled with Topical Hypotensive Medications.
Buffet J, Brasnu E, Baudouin C, Labbé A.
J Glaucoma. 2017 Oct 30. doi: 10.1097/IJG.0000000000000808.

Effect of Ultraviolet Light Irradiation Combined with Riboflavin on Different Bacterial Pathogens from Ocular Surface Infection.
Shen J, Liang Q, Su G, Zhang Y, Wang Z, Liang H, Baudouin C, Labbé A.
J Biophys. 2017;2017:3057329. doi: 10.1155/2017/3057329. Epub 2017 Oct 12.

One-year efficacy and safety of 0.1% cyclosporine A cationic emulsion in the treatment of severe dry eye disease.
Baudouin C, de la Maza MS, Amrane M, Garrigue JS, Ismail D, Figueiredo FC, Leonardi A.
Eur J Ophthalmol. 2017 Jul 1:0. doi: 10.5301/ejo.5001002.

TFOS DEWS II iatrogenic report.
Gomes JAP, Azar DT, Baudouin C, Efron N, Hirayama M, Horwath-Winter J, Kim T, Mehta JS, Messmer EM, Pepose JS, Sangwan VS, Weiner AL, Wilson SE, Wolffsohn JS.
Ocul Surf. 2017 Jul;15(3):511-538.

Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice.
Cwerman-Thibault H, Lechauve C, Augustin S, Roussel D, Reboussin É, Mohammad A, Degardin-Chicaud J, Simonutti M, Liang H, Brignole-Baudouin F, Maron A, Debeir T, Corral-Debrinski M.
Mol Ther Methods Clin Dev. 2017 Apr 27;5:200-220.

Lebecetin, a C-type lectin, inhibits choroidal and retinal neovascularization.
Montassar F, Darche M, Blaizot A, Augustin S, Conart JB, Millet A, Elayeb M, Sahel JA, Réaux-Le Goazigo A, Sennlaub F, Marrakchi N, Messadi E, Guillonneau X.
FASEB J. 2017 Mar;31(3):1107-1119.

Safety and efficacy of a hydroxypropyl guar/polyethylene glycol/propylene glycol-based lubricant eye-drop in patients with dry eye.
Labetoulle M, Messmer EM, Pisella PJ, Ogundele A, Baudouin C.
Br J Ophthalmol. 2017 Apr;101(4):487-492.

Clinical evaluation of an oil-based lubricant eyedrop in dry eye patients with lipid deficiency.
Baudouin C, Galarreta DJ, Mrukwa-Kominek E, Böhringer D, Maurino V, Guillon M, Rossi GC, Van der Meulen IJ, Ogundele A, Labetoulle M.
Eur J Ophthalmol. 2017 Mar 10;27(2):122-128.

Emerging strategies for the diagnosis and treatment of meibomian gland dysfunction: Proceedings of the OCEAN group meeting.
Geerling G, Baudouin C, Aragona P, Rolando M, Boboridis KG, Benítez-Del-Castillo JM, Akova YA, Merayo-Lloves J, Labetoulle M, Steinhoff M, Messmer EM
Ocul Surf. 2017 Apr;15(2):179-192.

Keratitis in Dry Eye Disease and Topical Ciclosporin A.
Leonardi A, Flamion B, Baudouin C.
Ocul Immunol Inflamm. 2017 Feb 1:1-10. doi: 10.1080/09273948.2016.1276933.

Effect of benzalkonium chloride on trabecular meshwork cells in a new in vitro 3D trabecular meshwork model for glaucoma.
Bouchemi M, Roubeix C, Kessal K, Riancho L, Raveu AL, Soualmia H, Baudouin C, Brignole-Baudouin F.
Toxicol In Vitro. 2017 Feb 16;41:21-29.

Effect of Surgical Intraocular Pressure Lowering on Peripapillary and Macular Vessel Density in Glaucoma Patients: An Optical Coherence Tomography Angiography Study.
Zéboulon P, Lévêque PM, Brasnu E, Aragno V, Hamard P, Baudouin C, Labbé A.
J Glaucoma. 2017 May;26(5):466-472.

A randomized study of the efficacy and safety of 0.1% cyclosporine A cationic emulsion in treatment of moderate to severe dry eye.
Baudouin C, Figueiredo FC, Messmer EM, Ismail D, Amrane M, Garrigue JS, Bonini S, Leonardi A.
Eur J Ophthalmol. 2017 Mar 20:0. doi: 10.5301/EJO.5000952.

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting.
Baudouin C, Irkeç M, Messmer EM, Benítez-Del-Castillo JM, Bonini S, Figueiredo FC, Geerling G, Labetoulle M, Lemp M, Rolando M, Van Setten G, Aragona P; ODISSEY European Consensus Group Members.
Acta Ophthalmol. 2017 Apr 8. doi: 10.1111/aos.13436.

A New Viscous Cysteamine Eye Drops Treatment for Ophthalmic Cystinosis: An Open-Label Randomized Comparative Phase III Pivotal Study.
Liang H, Labbé A, Le Mouhaër J, Plisson C, Baudouin C.
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2275-2283.

Ocular Surface and External Filtration Surgery: Mutual Relationships.
Baudouin C.
Dev Ophthalmol. 2017;59:67-79.

The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells.
Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA.
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2406-2412.

Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease.
Brignole-Baudouin F, Riancho L, Ismail D, Deniaud M, Amrane M, Baudouin C.
Vis Sci. 2017 Apr 1;58(4):2438-2448.

Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomised controlled trial in moderate to severe dry eye.Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomised controlled trial in moderate to severe dry eye.
Labetoulle M, Chiambaretta F, Shirlaw A, Leaback R, Baudouin C.
Eye (Lond). 2017 Apr 28.
2016

Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction
Baudouin C, Messmer EM, Aragona P, Geerling G, Akova YA, Benítez-Del-Castillo J, Boboridis KG, Merayo-Lloves J, Rolando M, Labetoulle M.
Br J Ophthalmol. 2016 Jan 18.

Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms.
Launay PS, Reboussin E, Liang H, Kessal K, Godefroy D, Rostene W, Sahel JA, Baudouin C, Melik Parsadaniantz S, Reaux Le Goazigo A.
Neurobiol Dis. 2016 Epub 2015 Dec 30.

Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat.
Sapienza A, Raveu AL, Reboussin E, Roubeix C, Boucher C, Dégardin J, Godefroy D, Rostène W, Reaux-Le Goazigo A, Baudouin C, Melik Parsadaniantz S.
J Neuroinflammation. 2016 Feb 20;13:44.

Efficacy and safety of a cationic emulsion in the treatment of moderate to severe dry eye disease: a randomized controlled study.
Robert PY, Cochener B, Amrane M, Ismail D, Garrigue JS, Pisella PJ, Baudouin C.
Eur J Ophthalmol. 2016 Aug 3:0. doi: 10.5301/ejo.5000830. [Epub ahead of print]

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells.
Warcoin E, Baudouin C, Gard C, Brignole-Baudouin F.
PLoS One. 2016 Aug 3;11(8):e0159983.

A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome.
Chiambaretta F, Doan S, Labetoulle M, Rocher N, Fekih LE, Messaoud R, Khairallah M, Baudouin C.
Eur J Ophthalmol. 2016 Jul 20:0. doi: 10.5301/ejo.5000836. [Epub ahead of print]

Safety and efficacy of a hydroxypropyl guar/polyethylene glycol/propylene glycol-based lubricant eye-drop in patients with dry eye.
Labetoulle M, Messmer EM, Pisella PJ, Ogundele A, Baudouin C. Br J Ophthalmol.
2016 Jul 15. pii: bjophthalmol-2016-308608. doi: 10.1136/bjophthalmol-2016-308608. [Epub ahead of print]

Potential Role of In Vivo Confocal Microscopy for Imaging Corneal Nerves in Transthyretin Familial Amyloid Polyneuropathy.
Rousseau A, Cauquil C, Dupas B, Labbé A, Baudouin C, Barreau E, Théaudin M, Lacroix C, Guiochon-Mantel A, Benmalek A, Labetoulle M, Adams D.
JAMA Ophthalmol. 2016 Sep 1;134(9):983-9. doi: 10.1001/jamaophthalmol.2016.1889.

Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53.
Kalouche G, Boucher C, Coste A, Debussche L, Orsini C, Baudouin C, Debeir T, Vigé X, Rostène W.
Biochim Biophys Acta. 2016 Sep;1863(9):2322-32.

In vivo confocal microscopy evaluation of ocular and cutaneous alterations in patients with rosacea.
Liang H, Randon M, Michee S, Tahiri R, Labbe A, Baudouin C.
Br J Ophthalmol. 2016 May 24. pii: bjophthalmol-2015-308110. doi: 10.1136/bjophthalmol-2015-308110. [Epub ahead of print]

A Severe Case of Pigmentary Glaucoma in a Child With a Family History of Pigment Dispersion Syndrome.
Aragno V, Zeboulon P, Baudouin C, Labbé A.
J Glaucoma. 2016 Aug;25(8):e745-7.

Evidence of seasonality and effects of psychrometry in dry eye disease.
van Setten G, Labetoulle M, Baudouin C, Rolando M.
Acta Ophthalmol. 2016 Aug;94(5):499-506.

Activation of Prostaglandin FP and EP2 Receptors Differently Modulates Myofibroblast Transition in a Model of Adult Primary Human Trabecular Meshwork Cells.
Kalouche G, Beguier F, Bakria M, Melik-Parsadaniantz S, Leriche C, Debeir T, Rostène W, Baudouin C, Vigé X.
Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1816-25.

Efficacy and safety of 0.1% cyclosporine A cationic emulsion in the treatment of severe dry eye disease: a multicenter randomized trial
Leonardi A, Van Setten G, Amrane M, Ismail D, Garrigue JS, Figueiredo FC, Baudouin C.
Eur J Ophthalmol. 2016 Jun 10;26(4):287-96.

Ocular Surface Epithelial Thickness Evaluation in Dry Eye Patients: Clinical Correlations.
Liang Q, Liang H, Liu H, Pan Z, Baudouin C, Labbé A.
J Ophthalmol. 2016;2016:1628469. doi: 10.1155/2016/1628469. Epub 2016 Jan 26.
2015

Dynamic Change of Optical Quality in Patients with Dry Eye Disease.Dynamic Change of Optical Quality in Patients with Dry Eye Disease.
Tan CH, Labbé A, Liang Q, Qiao LY, Baudouin C, Wan XH, Wang N.
Invest Ophthalmol Vis Sci. 2015 Feb 3. pii: IOVS-14-15757.

Dry Eye Disease after Refractive Surgery: Comparative Outcomes of Small Incision Lenticule Extraction versus LASIK.Dry Eye Disease after Refractive Surgery: Comparative Outcomes of Small Incision Lenticule Extraction versus LASIK.
Denoyer A, Landman E, Trinh L, Faure JF, Auclin F, Baudouin C.
Ophthalmology. 2015 Apr; 122(4): 669-76.

In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.
Randon M, Liang H, El Hamdaoui M, Tahiri R, Batellier L, Denoyer A, Labbé A, Baudouin C.
Br J Ophthalmol. 2015 Mar;99(3):336-41.

Cyclocoagulation of the ciliary bodies by High Intensity Focused Ultrasound (HIFU): a 12-month Multicenter Study.
Denis P, Aptel F, Rouland JF, Nordmann JP, Lachkar Y, Renard JP, Sellem E, Baudouin C, Bron A.
Invest Ophthalmol Vis Sci. 2015 Jan 20. pii: IOVS-14-14973.

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma.Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma.
Roubeix C, Godefroy D, Mias C, Sapienza A, Riancho L, Degardin J, Fradot V, Ivkovic I, Picaud S, Sennlaub F, Denoyer A, Rostene W, Sahel JA, Parsadaniantz SM, Brignole-Baudouin F, Baudouin C.
Stem Cell Res Ther. 2015 Sep 16;6:177. doi: 10.1186/s13287-015-0168-0.

Evaluation of Blebs After Filtering Surgery With En-Face Anterior-Segment Optical Coherence Tomography: A Pilot Study
Meziani L, Tahiri Joutei Hassani R, El Sanharawi M, Brasnu E, Liang H, Hamard P, Baudouin C, Labbe A.
J Glaucoma. 2015 Sep 14. [Epub ahead of print]

Evaluation of Optical Coherence Tomography Meibography in Patients With Obstructive Meibomian Gland Dysfunction.
Liang Q, Pan Z, Zhou M, Zhang Y, Wang N, Li B,Baudouin C, Labbé A.
Cornea. 2015 Oct;34(10):1193-9.

Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion.
Launay PS, Godefroy D, Khabou H, Rostene W, Sahel JA, Baudouin C, Melik-Parsadaniantz S, Reaux-Le Goazigo A.
Exp Eye Res. 2015 Jun 11. pii: S0014-4835(15)00196-7. doi: 10.1016/j.exer.2015.06.008. [Epub ahead of print]
PMID:26072022

The measurement of bulbar hyperemia: challenges and pitfalls.
Baudouin C, Barton K, Cucherat M, Traverso C.
Eur J Ophthalmol. 2015 May 25;25(4):273-9. doi: 10.5301/ejo.5000626. Epub 2015 May 21.
PMID:26069220

Photophobia and corneal crystal density in nephropathic cystinosis: an in vivo confocal microscopy and anterior-segment optical coherence tomography study.
Liang H, Baudouin C, Tahiri Joutei Hassani R, Brignole-Baudouin F, Labbe A.
Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3218-25. doi: 10.1167/iovs.15-16499.
PMID:26024106

Patient satisfaction with glaucoma therapy: reality or myth?
Lemij HG, Hoevenaars JG, van der Windt C, Baudouin C.
Clin Ophthalmol. 2015 May 4;9:785-93. doi: 10.2147/OPTH.S78918. eCollection 2015.
PMID:25999687

Dynamic change of optical quality in patients with dry eye disease.
Tan CH, Labbé A, Liang Q, Qiao L, Baudouin C, Wan X, Wang N.
Invest Ophthalmol Vis Sci. 2015 May 1;56(5):2848-54. doi: 10.1167/iovs.14-15757.
PMID:25650418

Cyclocoagulation of the ciliary bodies by high-intensity focused ultrasound: a 12-month multicenter study.
Denis P, Aptel F, Rouland JF, Nordmann JP, Lachkar Y, Renard JP, Sellem E, Baudouin C, Bron A.
Invest Ophthalmol Vis Sci. 2015 Jan 20;56(2):1089-96. doi: 10.1167/iovs.14-14973.
PMID:25604688

Dry eye disease after refractive surgery: comparative outcomes of small incision lenticule extraction versus LASIK.
Denoyer A, Landman E, Trinh L, Faure JF, Auclin F, Baudouin C.
Ophthalmology. 2015 Apr;122(4):669-76. doi: 10.1016/j.ophtha.2014.10.004. Epub 2014 Nov 22.
PMID:25458707
2014

Dry Eye Disease after Refractive Surgery: Comparative Outcomes of Small Incision Lenticule Extraction versus LASIK.
Denoyer A, Landman E, Trinh L, Faure JF, Auclin F, Baudouin C
Ophthalmology. 2014 Nov 22. pii: S0161-6420(14)00952-X. doi: 10.1016/j.ophtha.2014.10.004. [Epub ahead of print]

Glaucoma medications, preservatives and the ocular surface.
Aptel F, Labbé A, Baudouin C, Bron A, Lachkar Y, Sellem E, Renard JP, Nordmann JP, Rouland JF, Denis P.
J Fr Ophtalmol. 2014 Oct 14;37(9):728-736. doi: 10.1016/j.jfo.2014.06.005. [Epub ahead of print] Review. French.

En-face optical coherence tomography as a novel tool for exploring the ocular surface: a pilot comparative study to conventional B-scans and in vivo confocal microscopy.
Tahiri Joutei Hassani R, Liang H, El Sanharawi M, Brasnu E, Kallel S, Labbé A, Baudouin C.
Ocul Surf. 2014 Oct;12(4):285-306. doi: 10.1016/j.jtos.2014.02.006. Epub 2014 Jul 11.

Evaluation of an eyelid warming device (Blephasteam(®)) for the management of ocular surface diseases in France: The ESPOIR study.
Doan S, Chiambaretta F, Baudouin C; ESPOIR study group.
J Fr Ophtalmol. 2014 Dec;37(10):763-72. doi: 10.1016/j.jfo.2014.06.004. Epub 2014 Oct 1.

Open-angle glaucoma secondary to Cushing syndrome related to an adrenal adenoma: Case report.
Virevialle C, Brasnu E, Fior R, Baudouin C.
J Fr Ophtalmol. 2014 Dec;37(10):e169. doi: 10.1016/j.jfo.2014.01.018. Epub 2014 Sep 26. No abstract available.

"En face" anterior segment optical coherence tomography findings in acute corneal hydrops.
Kallel S, Tahiri Joutei Hassani R, Liang H, Baudouin C, Labbé A.
J Fr Ophtalmol. 2014 Oct;37(8):605-12. doi: 10.1016/j.jfo.2014.04.008. Epub 2014 Sep 26. French.

In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.
Randon M, Liang H, El Hamdaoui M, Tahiri R, Batellier L, Denoyer A, Labbé A, Baudouin C.
Br J Ophthalmol. 2014 Sep 24. pii: bjophthalmol-2014-305671. doi: 10.1136/bjophthalmol-2014-305671. [Epub ahead of print]

Filtering surgery in-office follow up.
Fenolland JR, Renard JP, Baudouin C, Hamard P.
J Fr Ophtalmol. 2014 Aug 23. pii: S0181-5512(14)00219-8. doi: 10.1016/j.jfo.2014.07.002. [Epub ahead of print] French. No abstract available.

Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease - a randomised comparative study.
Amrane M, Creuzot-Garcher C, Robert PY, Ismail D, Garrigue JS, Pisella PJ, Baudouin C.
J Fr Ophtalmol. 2014 Oct;37(8):589-98. doi: 10.1016/j.jfo.2014.05.001. Epub 2014 Aug 13.

Increased Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Expression in the Conjunctival Epithelium Exposed to Antiglaucoma Treatments.
Labbé A, Gabison E, Brignole-Baudouin F, Riancho L, Menashi S, Baudouin C.
Curr Eye Res. 2015 Jan;40(1):40-7. doi: 10.3109/02713683.2014.915574. Epub 2014 May 15.

Rethinking dry eye disease: a perspective on clinical implications.
Bron AJ, Tomlinson A, Foulks GN, Pepose JS, Baudouin C, Geerling G, Nichols KK, Lemp MA.
Ocul Surf. 2014 Apr;12(2 Suppl):S1-31. doi: 10.1016/j.jtos.2014.02.002. Epub 2014 Feb 13. Review.

Reis-Bücklers corneal dystrophy: a reappraisal using in vivo and ex vivo imaging techniques.
Liang Q, Pan Z, Sun X, Baudouin C, Labbé A.
Ophthalmic Res. 2014;51(4):187-95. doi: 10.1159/000358805. Epub 2014 Mar 20.

Diagnosing the severity of dry eye: a clear and practical algorithm.
Baudouin C, Aragona P, Van Setten G, Rolando M, Irkeç M, Benítez del Castillo J, Geerling G, Labetoulle M, Bonini S; ODISSEY European Consensus Group members.
Br J Ophthalmol. 2014 Sep;98(9):1168-76. doi: 10.1136/bjophthalmol-2013-304619. Epub 2014 Mar 13.

Can breast implants be responsible for dry eye?
Virevialle C, Labbé A, Dupont-Monod S, Parent F, Baudouin C.
Eye (Lond). 2014 May;28(5):633-4. doi: 10.1038/eye.2014.6. Epub 2014 Mar 7. No abstract available.

Femtosecond and excimer laser-assisted endothelial keratoplasty (FELEK): a new technique of endothelial transplantation.
Trinh L, Saubaméa B, Auclin F, Denoyer A, Lai-Kuen R, El Hamdaoui M, Labbé A, Despiau MC, Brignole-Baudouin F, Baudouin C.
J Fr Ophtalmol. 2014 Mar;37(3):211-9. doi: 10.1016/j.jfo.2013.07.009. Epub 2014 Feb 18.

Bone sialoprotein as a potential key factor implicated in the pathophysiology of osteoarthritis.
Pesesse L, Sanchez C, Walsh DA, Delcour JP, Baudouin C, Msika P, Henrotin Y.
Osteoarthritis Cartilage. 2014 Apr;22(4):547-56. doi: 10.1016/j.joca.2014.01.010. Epub 2014 Feb 13.

Development and organization of human stratum corneum after birth: electron microscopy isotropy score and immunocytochemical corneocyte labelling as epidermal maturation's markers in infancy.
Fluhr JW, Lachmann N, Baudouin C, Msika P, Darlenski R, De Belilovsky C, Bossert J, Colomb E, Burdin B, Haftek M.
Br J Dermatol. 2014 Nov;171(5):978-86. doi: 10.1111/bjd.12880. Epub 2014 Oct 3.

Prospective, unmasked evaluation of the iStent® inject system for open-angle glaucoma: synergy trial.
Voskanyan L, García-Feijoó J, Belda JI, Fea A, Jünemann A, Baudouin C; Synergy Study Group.
Adv Ther. 2014 Feb;31(2):189-201. doi: 10.1007/s12325-014-0095-y. Epub 2014 Jan 23.

A new gel formulation of topical cysteamine for the treatment of corneal cystine crystals in cystinosis: the Cystadrops OCT-1 study.
Labbé A, Baudouin C, Deschênes G, Loirat C, Charbit M, Guest G, Niaudet P.
Mol Genet Metab. 2014 Mar;111(3):314-20. doi: 10.1016/j.ymgme.2013.12.298. Epub 2014 Jan 9.

In vivo confocal microscopy of the ocular surface: from bench to bedside.
Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M.
Curr Eye Res. 2014 Mar;39(3):213-31. doi: 10.3109/02713683.2013.842592. Epub 2013 Nov 11. Review.

Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve.
Van Steenwinckel J, Auvynet C, Sapienza A, Reaux-Le Goazigo A, Combadière C, Melik Parsadaniantz S.
Brain Behav Immun. 2014 Nov 4. pii: S0889-1591(14)00513-3. doi: 10.1016/j.bbi.2014.10.016. [Epub ahead of print]

Chemokines and attraction of myeloid cells in peripheral neuropathic pains.
Sapienza A, Réaux-Le Goazigo A, Rostène W, Mélik-Parsadaniantz S.
Biol Aujourdhui. 2014;208(1):31-44. doi: 10.1051/jbio/20140011. Epub 2014 Jun 23. French.

Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation.
Belkouch M, Dansereau MA, Tétreault P, Biet M, Beaudet N, Dumaine R, Chraibi A, Mélik-Parsadaniantz S, Sarret P.
J Neuroinflammation. 2014 Mar 7;11:45. doi: 10.1186/1742-2094-11-45.

Src family kinases involved in CXCL12-induced loss of acute morphine analgesia.
Rivat C, Sebaihi S, Van Steenwinckel J, Fouquet S, Kitabgi P, Pohl M, Melik Parsadaniantz S, Reaux-Le Goazigo A.
Brain Behav Immun. 2014 May;38:38-52. doi: 10.1016/j.bbi.2013.11.010. Epub 2013 Nov 18.
2013

Reaux-Le Goazigo A, Van Steenwinckel J, Rostene W, Mélik Parsadaniantz S.
Current status of chemokines in the adult CNS. Prog Neurobiol. 2013 May;104:67-92.

Dauvergne C, Molet J, Reaux-Le Goazigo A, Mauborgne A, Melik-Parsadaniantz S, Boucher Y, Pohl M. Implication of the chemokine CCL2 in trigeminal nociception and traumatic neuropathic orofacial pain. Eur J Pain. 2013 Aug 5.

Rivat C, Sebaihi S, Van Steenwinckel J, Fouquet S, Kitabgi P, Pohl M, Melik Parsadaniantz S, Reaux-Le Goazigo A. Src family kinases involved in CXCL12-induced loss of acute morphine analgesia. Brain Behav Immun. 2013 Nov 18.
2012

Denoyer A, Godefroy D, Célérier I, Frugier J, Riancho L, Baudouin F, Rostène W, Baudouin C. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol, 2012; 5:702-711.

Denoyer A, Godefroy D, Célérier I, Frugier J, Degardin J, Harrison JK, Brignole-Baudouin F, Picaud S, Baleux F, Sahel JA, Rostène W, Baudouin C. CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension. PLoS One. 2012;7(6):e37873.

Brignole-Baudouin F, Desbenoit N, Hamm G, Liang H, Both JP, Brunelle A, Fournier I, Guerineau V, Legouffe R, Stauber J, Touboul D, Wisztorski M, Salzet M, Laprevote O, Baudouin C. A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits.PLoS One. 2012;7(11):e50180

Labbe A, Alalwani H, Van Went C, Brasnu E, Georgescu D, Baudouin C. The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease.Invest Ophthalmol Vis Sci. 2012;53(8):4926-31.

Chassignol A, Brasnu E, Baudouin C, Riancho L, Warnet JM,Brignole-Baudouin F. In vitro interactions between peripheral blood lymphocytes and Wong-Kilbourne derivative of Chang conjunctival cells. Invest Ophthalmol Vis Sci. 2012 Feb 10.

Baudouin C, Cochener B, Pisella PJ, Girard B, Pouliquen P, Cooper H, Creuzot-Garcher C.Randomized, phase III study comparing osmoprotective carboxymethylcellulose with sodium hyaluronate in dry eye disease.Eur J Ophthalmol. 2012 Jan 27
2011

Van Steenwinckel J, Reaux-Le Goazigo A, Pommier B, Mauborgne A, Dansereau MA, Kitabgi P, Sarret P, Pohl M, Mélik Parsadaniantz S.CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. J Neurosci. 2011; 31(15):5865-75.

Brignole-Baudouin F, Riancho L, Liang H, Baudouin C.Comparative in vitro toxicology study of travoprost polyquad-preserved, travoprost BAK-preserved, and latanoprost BAK-preserved ophthalmic solutions on human conjunctival epithelial cells. Curr Eye Res. 2011 Nov;36(11):979-88.

Pflugfelder SC, Baudouin C.Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clin Ophthalmol. 2011;5:1575-83.

Francoz M, Karamoko I, Baudouin C, Labbé A. Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 Nov 25;52(12):9116-23.

Luyckx J, Baudouin C. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin Ophthalmol. 2011;5:577-81.

Lemp MA, Bron AJ, Baudouin C, Benítez Del Castillo JM, Geffen D, Tauber J, Foulks GN, Pepose JS, Sullivan BD. Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol. 2011May;151(5):792-798.

Van Went C, Brasnu E, Hamard P, Baudouin C, Labbé A. [The influence of ocular surface diseases in the management of glaucoma]. J Fr Ophtalmol.2011 Apr;34(4):230-7.

Pauly A, Brasnu E, Riancho L, Brignole-Baudouin F, Baudouin C. Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model. Mol Vis. 2011 Mar 16;17:745-55.

Liang H, Pauly A, Riancho L, Baudouin C, Brignole-Baudouin F. Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system. Br J Ophthalmol. 2011 Jun;95(6):869-75.

Liang H, Brignole-Baudouin F, Pauly A, Riancho L, Baudouin C.Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: a rabbit ocular surface study. Adv Ther. 2011 Apr;28(4):311-25.

Mehanna C, Baudouin C, Brignole-Baudouin F. Spectrofluorometry assays for oxidative stress and apoptosis, with cell viability on the same microplates: A multiparametric analysis and quality control. Toxicol In Vitro. 2011 Aug;25(5):1089-96.

Brignole-Baudouin F, Riancho L, Liang H, Nakib Z, Baudouin C. In vitro comparative toxicology of polyquad-preserved and benzalkonium chloride-preserved travoprost/timolol fixed combination and latanoprost/timolol fixed combination. J Ocul Pharmacol Ther. 2011 Jun;27(3):273-80.

Labbé A, Gabison E, Cochereau I, Baudouin C. Diagnosis of fungal keratitis by in vivo confocal microscopy: a case report. Eye (Lond). 2011 Jul;25(7):956-8.

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